Exploring a new, connective Pummerer reaction: formation of oxindoles by the reaction of thiols with glyoxamides.
نویسندگان
چکیده
The reaction of a range of thiols with mono- and bis-glyoxamides derived from secondary anilines, triggers a new, connective Pummerer cyclisation process and leads to the formation of oxindoles.
منابع مشابه
Formation of N-heterocycles by the reaction of thiols with glyoxamides: exploring a connective Pummerer-type cyclisation.
The reaction of thiols with glyoxamides provides a convenient method for the generation of thionium ions and the initiation of Pummerer-type reactions. When the glyoxamides contain tethered aromatic nucleophiles, N-heterocycles are formed by a thionium ion cyclisation. The scope and mechanism of the connective Pummerer-type process has been investigated using a range of thiols, Lewis acids and ...
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ورودعنوان ژورنال:
- Chemical communications
دوره 5 شماره
صفحات -
تاریخ انتشار 2007